Bingo Blitz contains Power-Ups that help you reach a bingo. The cards also contain Bonus Squares that award you with additional in-game prizes when you manage to mark them off. A full game of Bingo Blitz could have anywhere between 10 and 15 rounds.
There's no guaranteed safe bet or strategy that will consistently lead to winning in the long run. However, some players choose to bet on even-money options such as red or black, odd or even, or high or low numbers, as these have the highest probability of winning.